John Vane vs Ernst Chain

John Vane was a British pharmacologist who shared the 1982 Nobel Prize in Physiology or Medicine for his research on hormone-like substances known as prostaglandins. He discovered that aspirin and other nonsteroidal anti-inflammatory drugs work by inhibiting the synthesis of prostaglandins, thereby reducing pain, inflammation, and fever. His biochemical assays allowed him to measure the effect of...

Ernst Chain (1906–1979) was a German-born British biochemist who fled Nazi Germany and joined Howard Florey's laboratory at the University of Oxford's Sir William Dunn School of Pathology. Together with Florey and Norman Heatley, Chain developed methods to extract and purify penicillin from Alexander Fleming's mold cultures in sufficient quantity for clinical trials in 1941. Chain, Florey, and Fle...