EteRNA

EteRNA is a browser-based citizen science game developed in 2011 by researchers at Carnegie Mellon University and Stanford University. The platform allows players to solve puzzles by designing RNA sequences that fold into specific shapes. It functions similarly to other protein-folding games but focuses specifically on ribonucleic acid.

Yes, the top designs synthesized by players are regularly selected and physically synthesized in a laboratory at Stanford University. The researchers test the RNA sequences to see if they fold in reality exactly as predicted in the game. The lab results are then fed back into the game to improve the scientific algorithms.

The game relies on crowdsourced solutions from thousands of non-expert players, including hobbyists and puzzle enthusiasts, to generate new scientific knowledge. Over 100,000 players have participated in the game since its launch. These citizen scientists frequently outperform standard computer algorithms in finding optimal folding sequences.

No, EteRNA is specifically designed to be accessible to the general public, teaching players the rules of RNA folding through interactive, game-like tutorials. Anyone with a web browser can learn how to manipulate the nucleotide bases to create stable molecular shapes. The intuitive interface bridges the gap between complex biochemistry and casual gaming.