50/50

Yes, the 2011 comedy-drama 50/50 is based on the real-life experiences of its screenwriter, Will Reiser, who was diagnosed with spinal cancer. Reiser wrote the film after surviving his own battle with the disease, drawing heavily on his friendship with actor Seth Rogen. Rogen stars in the movie alongside Joseph Gordon-Levitt, who plays the fictionalized version of Reiser.

Joseph Gordon-Levitt's character, Adam Lerner, is diagnosed with a rare type of malignant tumor known as schwannoma neurofibrosarcoma. Specifically, it is a cancer of the schwann cells in the spine. This specific diagnosis was adapted from screenwriter Will Reiser's actual medical condition.

Anna Kendrick portrays Katie McKay, the inexperienced clinical psychology doctoral student assigned as Adam's therapist. Her character provides both emotional support and a romantic subplot in the 2011 film. Kendrick's performance earned her critical praise for balancing the anxiety of a new therapist with genuine empathy.

While it didn't win an Academy Award, 50/50 received a Golden Globe nomination for Best Motion Picture - Musical or Comedy in 2011. Joseph Gordon-Levitt also earned a Golden Globe nomination for Best Actor in a Musical or Comedy. The film was widely praised by critics and took home the National Board of Review's Top Films award.