description Peter Agre Overview
Peter Agre is an American physician-scientist who conducted his Nobel Prize-winning research at Johns Hopkins University. He shared the 2003 Nobel Prize in Chemistry with Roderick MacKinnon for discoveries concerning channels in cell membranes, specifically for the discovery of aquaporins. Agre identified aquaporin-1 as the protein responsible for selective water transport across cell membranes, solving a long-standing question of how cells regulate water flow. His findings have implications for understanding diseases involving fluid imbalance, including kidney dysfunction, cataracts, and brain edema.
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What specific cell membrane structure did Peter Agre discover?
Peter Agre discovered aquaporins, which are specialized channel proteins that facilitate the rapid movement of water across cell membranes. This solved a long-standing biological mystery of how cells efficiently regulate their water intake and output.
Where did Peter Agre conduct his Nobel Prize-winning research?
He conducted his award-winning research at Johns Hopkins University. He accidentally discovered the first aquaporin, initially called CHIP28, while studying the Rh blood group antigens.
With whom did Peter Agre share the 2003 Nobel Prize in Chemistry?
He shared the 2003 Nobel Prize in Chemistry with Roderick MacKinnon. While Agre was honored for discovering water channels, MacKinnon was honored for his structural and mechanistic studies of ion channels.
In what year was Peter Agre awarded the Nobel Prize?
Peter Agre was awarded the Nobel Prize in Chemistry in 2003. His discovery of aquaporins has had major implications for understanding diseases affecting water homeostasis, like cataracts and kidney dysfunction.
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