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Arthur Harden

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description Arthur Harden Overview

Arthur Harden was a British biochemist who shared the 1929 Nobel Prize in Chemistry with Hans von Euler-Chelpin for their work on the fermentation of sugar and fermentative enzymes. He was specifically recognized for elucidating the role of phosphorylation in carbohydrate metabolism. His research significantly advanced the understanding of biochemical processes in yeast.

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What did Arthur Harden discover in biochemistry?

Arthur Harden was a British biochemist who discovered that phosphorylation plays a critical role in carbohydrate metabolism, specifically in the breakdown of sugars by enzymes. He co-discovered the coenzyme now known as NAD+ (nicotinamide adenine dinucleotide), which is fundamental to cellular energy processes.

When did Arthur Harden win the Nobel Prize?

Arthur Harden was awarded the Nobel Prize in Chemistry in 1929, sharing it with Hans von Euler-Chelpin for their independent work on the fermentation of sugars and the role of enzymes in that process. Harden's specific contributions centered on the identification of a heat-stable coenzyme in yeast juice.

Where did Arthur Harden conduct his research?

Harden spent most of his career at the Lister Institute of Preventive Medicine in London, where he led the biochemistry department. He conducted his groundbreaking work on fermentation and enzyme chemistry there from the late 1890s through the 1920s.

What is Arthur Harden's connection to glycolysis?

Harden's research on the fermentation of glucose by yeast juice contributed foundational knowledge to what would later be called the glycolysis pathway, sometimes referred to as the Embden-Meyerhof-Parnas pathway. His discovery of the coenzyme he called "cozymase" (later identified as NAD+) was essential to understanding how cells break down glucose for energy.