description James B. Sumner Overview
James B. Sumner (1887–1955) was an American chemist at Cornell University who, in 1926, crystallized the enzyme urease from jack beans. This was the first time an enzyme had been isolated in crystalline form, demonstrating that enzymes are proteins with defined structures. Sumner lost his left arm in a hunting accident at age 17 but continued his laboratory work.
He shared the 1946 Nobel Prize in Chemistry with John Howard Northrop and Wendell Meredith Stanley.
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James B. Sumner ranks #172 of 203 in the Chemist ranking, behind Arthur Harden, ahead of Larry Overman.
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What enzyme did James B. Sumner successfully crystallize in 1926?
In 1926, James B. Sumner successfully isolated and crystallized the enzyme urease. He extracted this enzyme from jack beans, marking a massive breakthrough in biochemistry.
Why was James B. Sumner's crystallization of urease historically significant?
By isolating urease in crystalline form, Sumner provided definitive proof that enzymes are actually proteins. Prior to this breakthrough, the exact chemical nature of enzymes was heavily debated among scientists.
Did James B. Sumner receive a Nobel Prize for his biochemical research?
Yes, James B. Sumner was awarded the Nobel Prize in Chemistry in 1946. He shared the prize with John Howard Northrop and Wendell Meredith Stanley for their collective work on purifying and crystallizing enzymes.
Where did James B. Sumner conduct his famous enzyme research?
Sumner conducted his Nobel-winning research while working at Cornell University. Despite losing his left arm in a hunting accident early in his career, he built a highly successful laboratory there.
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